Researchers from Pritzker Molecular Engineering, under the guidance of Prof. Jeffrey Hubbell, demonstrated that their compound can eliminate the autoimmune response linked to multiple sclerosis. Researchers at the University of Chicago’s Pritzker School of Molecular Engineering (PME) have developed
Psoriasis? Plz.
Yeah, pretty please.
Psoriatic arthritis recently manifested itself after just struggling with psoriatic nails and a little on my scalp. I’m only 33 and in the mornings I have absolutely 0 fine motor skills and it’s difficult to do things like unlock my front door when I leave for work. Painful as well. My dermatologist referred me to a rheumatologist….1 year for an appointment. No joke.
I hope you get help soon!
I had large amount of psoriasis spots on my arms and legs and also developed arthritis and for me Humira helped immensely.
No more pain and spots.
I cannot WAIT to get put on something like that. Happy you’re doing well.
My psoriasis went away completely after getting rid of/managing my mast cell activation syndrome, which was in turn caused by compression of the bottom of my spine
Some food for thought
This honestly sounds like what I’ve been experiencing for months and my Dr can’t figure it out, the leading guess right now is long covid. I noticed on the Wikipedia page it even mentions long covid, are they similar? Does your lymph node randomly swell up?
Long covid is very similar to MCAS
Yeah lymph nodes in my head would randomly feel swollen
Can you elaborate?
About what part?
What happened in your spine, how did you detect it?
There seems to be some compression in or around the cauda equina, I found out by pure fluke. I noticed I got a lot worse with the MCAS after doing hip thrusts with weights and after anything else that bends the lower back. Decided to hold my lower back really rigidly straight for a few days and my health issues were practically gone, and have been since.
There seems to be a few case reports online of people with MCAS getting a full cure after spinal decompression surgery but I think they had tethered cord syndrome.
Not sure what the best long term solution will be, need to find out why those nerves get crushed when bending but scans thus far are inconclusive
My wife has Type 1 diabetes and I have UC.
This would be a god-send, but Im not gonna hold my breath. Good news is always a lie.
I’ve had Type 1 Diabetes since I was 6. It’s always 20 years away. I’m 32 now.
Very often, headlines about new, revolutionary medical breakthroughs actually do result in breakthrough treatments for specific niche disease scenarios. For instance, cancer deaths are down roughly 1/3 over the past 30 years.
The research is interesting, but I don’t appreciate the bullshit clickbait headline.
I wonder what the implications for transplant recipients are.
That’s the holy grail for this type of research. Autoimmune cures are seen as a stepping stone for that
Notably they trialled first for coeliac autoimmune, but it’ll be 2024 before phase 2 results are out for that. About 10 years back there was a similar vaccine which also passed phase 1 trials but failed at phase 2. Phase 1 is basically testing that the vaccine does no harm in small groups and it is phase 2 where they measure if it is actually efficacious and to what level. If it passes phase 2, then get your hopes up.
I work in clinical (and preclinical) trials. And I have celiac disease. I’m hopeful but not optimistic that I’ll be able to eat pasta within the next decade.
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Well it wouldn’t grow my colon back but I’ll take what I can get!
Right?! Just a way to be able to live somewhat normally would be amazing!
I wonder if it’ll be an anti-autoimmunity for life, or if we’d have to get regular doses like with Remicade.
This just got me and I needed a good laugh so thank you.
Going on my seventht day of COVID, getting worse, and my scumbag immune system has decided this isn’t nearly as interesting as the large intestine and everything south of it that it took a few years back.
C’mon, little help here?!
I got COVID before the vaccines came out and I was surprisingly unfased by it, I was iffy for a few days but besides not being able to taste or smell for about 6 months I was fine. My wife however had to be hospitalised and she’s healthier than I am so I feel like I got very lucky.
I hope you get through it quickly and start feeling better!
Thank you, I had it before and pulled through ok, I started feeling better after an epic nap today.
Must have been terrifying for you while your wife was ill.
A few months before anyone even heard of COVID a friend of ours who was a runner and what not was in the ICU with double pneumonia for a long time and they had no idea at all what it was. We all assume it was COVID now but no one said it was (it’s not like they could have tested her for it). Pretty wild.
Maybe pig colons are next up on the transplant list.
Man I don’t know if I want more surgery at this point, but solid poops would be interesting I guess.
I’m good. I’m in and out in minutes. Yes, I get less reading done, but I have way more time for other activities.
Edit: plus road trips are so much better, no more dealing with horrifyingly gross gas station bathrooms.
Not gonna lie, I’m gonna be salty for a long time if a shot can fix my Crohn’s, since about 6 years ago I got a permanent ostomy bag -_- can’t give me back my ass hole.
They’ve had some real breakthroughs growing organs in pigs so don’t lose hope, you might get both at the same time!
Same. Lol.
Every time I read or hear about ablations, I cant help having a thought about the phantom pain phenomenon. In your that that would be a real pain in the ass.
I have had the same operation and sometimes feel like I have to “go”. It’s really weird. Sorry if tmi.
This is really amazing if true. They should not call it a vaccine or else hardly anyone will get it…
It’s more of an anti-vaccine, rather than conferring immune response it removes it.
I doubt that people suffering from MS, T1, Crohn’s, Celiac etc would be discouraged by the term. It’s not a prophylactic vaccine intended for the general population.
Lol I know that. I’m saying that there are more people than ever that are immediately wary of anything that is called a vaccine. You’re probably right that the ppl this directly impacts wouldn’t think the government put micro chips in it.
Natural selection at work. It is a super duper vaccine!
I guess there are rude people here as well as reddit. Sigh.
I have MS, I’ll go wild once I hear it’s approved. Until then I’ll save my energy.
Let’s not put the cart before the horse.
… But also I’d like to point out that celiac is an autoimmune disease, so for some people this may be a vaccine against gluten free bread.
so for some people this may be a vaccine against gluten free bread
The most marvelous medicine in the history of humanity.
My son (who is 9) was diagnosed with celiac when he didn’t grow from age 2-3 (gluten -> guts make enzyme to digest it -> immune system sees enzyme making cells as invaders -> immune system attacks cells -> intestines swell -> nutrition stops being absorbed). He was effectively starving despite eating. He’s on track now as we have a strict gluten free household, and the fad people have created a market demand which makes companies want to make products that give him options…but a treatment like this would be life changing.
The good thing for him is that he was so young when he was diagnosed that he probably doesn’t know anything else. Saying this from personal experience as I was diagnosed at 14 months in mid 80s. Of course, something like this would be amazing as I can’t tolerate even small amounts of accidental gluten but as I don’t know anything else I can’t even imagine anything else.
Aye, the difference between me, diagnosed in preteens, and my friend, diagnosed at 3, is immense. I still have the odd craving and sometimes indulge with stupid results. She? Never even crosses her mind.
… initial phase I safety trials have already been carried out in people with celiac disease …
Not being snarky, just relating the article to your statement.
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Our immune systems are both one of the most fascinating things about us and for those with autoimmune issues like myself, the most annoying. Always good to see articles like this and I’m glad this focused on the actual science.
I’d love to sign up for the trial if they ever test it for vitiligo. There are wayyy more serious autoimmune issues that can and should be tested first for those truly suffering. Mine is just “hey look at weird color boy”.
Immune systems are wild, and it’s also wild how they can go spectacularly wrong in different ways. Autoimmune diseases run in families, but not necessarily the same disease. My great-aunt has Crohn’s. My dad and big brother both have segmental vitiligo (dad, just on the back of his neck and a shoulder, my brother on one arm), but my immune system decided my thyroid was the enemy. Like. Not fair, body. 🤣
Finally i can stop shitting my pants
Yeah, sure 🙄
It’s tough to see promising treatments and cures for Type 1. There have been huge inroads for treatment but a cure always seems just around the corner. Here’s to hope for all the Type 1’s and thank you for all the people looking to find that cure.
Lol, just around the corner is right. My doctor, waaaay back in the 90s, said a cure was 10-15 years away. I think it’s just language they use. Especially when they are talking to the extremely sick/depressed who just learned what they have.
It usually is that close, but that’s assuming unlimited funding… Imagine if anything else had the funding that COVID did.
