Vaccines can be delivered through the skin using ultrasound. This method doesn’t damage the skin and eliminates the need for painful needles. To create a needle-free vaccine, Darcy Dunn-Lawless at the University of Oxford and his colleagues mixed vaccine molecules with tiny, cup-shaped proteins. They then applied liquid mixture to the skin of mice and exposed it to ultrasound – like that used for sonograms – for about a minute and a half.

  • @[email protected]
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    42 years ago

    This seems suspicious, I’m not sure if it won’t work at all or will kill you, but I wouldn’t go near these without significant testing.

    • shastaxc
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      32 years ago

      I’m thinking getting the dosage right will be very difficult

      • silly goose meekah
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        42 years ago

        The article says that the dosage is about 700x lower but more antibodies are created. So it doesn’t seem like that’s a real issue

    • Neato
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      At first, the ultrasound pushed the mixture into the upper layers of skin, where the shape of the proteins caused vaccine-filled bubbles to form. As ultrasound kept hitting the skin, those bubbles burst and released the vaccine. As the experiment went on, the action of the bubbles breaking also cleared some dead skin cells, making the skin more permeable and allowing more and more vaccine molecules make it through.

      A needle pushes vaccine molecules all the way into the muscles beneath the skin, while the ultrasound technique just delivers the vaccine to the upper layers of skin. But this more shallow process is sufficient for immunisation, says Dunn-Lawless.

      In tests with live mice, the researchers found that while the ultrasound method delivered 700 times fewer molecules of vaccine than conventional jabs, the animals produced more antibodies. The researchers say that the mice didn’t show signs of pain and there was no visible damage to their skin.

      Neat. I’m wondering about the effectiveness with thicker skin in humans.

  • @[email protected]
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    1672 years ago

    While this is awesome, I can already imagine anti-vaxxers are now deathly afraid of ultrasounds lol

    • @[email protected]
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      92 years ago

      Wanna bet that they will somehow combine this with 5G conspiracies?

      “It’s all just a wave after all!!!” /s

    • silly goose meekah
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      82 years ago

      Idk, anti vaxxers aren’t afraid of needles/syringes as far as I understand. They don’t want that kind of substance to be put inside their body, regardless of the method of administration

    • @[email protected]
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      2 years ago

      Brace yourselves! Vaccination with sound conspiracies coming in!

      “The IRS called, they vaccinated me trough my phone in my ear!!?”

      “Mass vaccinations trough radio!!?”

      • @[email protected]
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        152 years ago

        As much as I hate fucking mobile alerts, they already thought the last test was some magical bullshit.

        • @[email protected]
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          52 years ago

          Ya see that one where someone’s landlord went loopy and cut power to their building because he’d consumed a bunch of conspiracy nut stuff?

          • @[email protected]
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            12 years ago

            I didn’t but I’m not surprised. I feel like this mystical thinking is rooted in our acceptance of religion to some extent.

        • @[email protected]
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          22 years ago

          I know you are joking, but I suspect that many people would swallow this idea while without any thought whatsoever.

          Yes, we live in an age of uncritical thought.

    • bruhduh
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      82 years ago

      When they’ll hear about it they’ll make ultrasound themselves)

    • @[email protected]
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      142 years ago

      They were already terrified of phone signals.

      Only fast ones though. Slower ones can’t penetrate the skin.

      • @[email protected]
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        142 years ago

        Hilariously enough, it’s closer to the other way 'round. Higher frequencies means more bandwidth but they can be blocked easier. Lower frequencies can go farther before being attenuated too much.

        • @[email protected]
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          82 years ago

          One of my friend’s friends has a PhD in psychology, but she thinks that nuclear radiation has healing properties and told me to move out of NYC because there was too much 5G everywhere. She still uses a smartphone though, just on a selfie stick on speakerphone 🤣 She also told me that she was afraid of the radio in her car because of the radio waves.

          • @[email protected]
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            02 years ago

            She thinks that nuclear radiation has healing properties

            In a way she’s actually not wrong. That’s what radiotherapy is. Focused nuclear radiation to heal cancer.

            • @[email protected]
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              32 years ago

              She doesn’t have cancer though, she’s perfectly healthy and is an “alternative medicine practitioner”. She said she sleeps with a piece of thorium under her pillow.

              Regardless of it being used for cancer treatment, nuclear radiation isn’t good for the body in any way. Various forms of radiation (not just nuclear) are harmful, like getting too much sun.

                • @[email protected]
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                  22 years ago

                  I’m convinced that she’s just nuts. My friend, who is her friend (how I met this woman), told me that the woman has started “Urine Therapy” and I just said “Jesus fucking Christ… I… I just have nothing to say” because I didn’t wanna get into a debate with him about it.

          • @[email protected]
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            42 years ago

            She could at least use wired headphones. Or is it one simple trick to stop people from calling you?

    • @[email protected]
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      372 years ago

      Since vaginal ultrasound is how they detect a “fetal heartbeat” at 6 weeks (the heart isn’t yet formed or pushing any blood, but there’s an electronic pulse) at which point abortion is illegal in many states, that might be a good thing.

      Although, as ultrasound is also how my overdue fetus was diagnosed with the umbilical cord wrapped 3x around the neck, leading to a quick C-section and healthy baby, I would rather keep the ultrasound machines and lose the lunatics.

      • @[email protected]
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        2 years ago

        at which point abortion is illegal in many states, that might be a good thing.

        It’s about 3 months here (Swiss). I think that is when neuronal tissue forms?

      • ugh
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        82 years ago

        They don’t care about women who are considering abortion. I’d be more worried that they’d implement a less reliable test.

    • The Barto
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      162 years ago

      The ultrasound waves are how they activate the 5g tracking chips, it’s all in their plan I got from this website I found on page 68 of Google.

  • Paul J
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    292 years ago

    I’m diabetic. This would be awesome!!

    • The Menemen!
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      12 years ago

      Will anyone actually do this, if it takes 1-1.5 minutes and needs a heavy machine?

        • @[email protected]
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          12 years ago

          I’m sure there are some people that would help, but I went from blood draws making me nearly pass out to self injecting meth(otrexate) once a week after my RA diagnosis.

          • @[email protected]
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            22 years ago

            A blood draw ruins my week (not exaggerated). If I were diagnosed with diabetes I would end up dead. For me, anything that avoids a needle is worth it.

            • @[email protected]
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              12 years ago

              Exactly. For you it’d likely be worth it. For people like me it’d be a waste - the answer was to nut up. I also require hour-long transfusions every two months. I’m not sure they could do anything but maybe put you under anesthesia for something like that.

              • @[email protected]
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                12 years ago

                Yeah, I really can’t imagine. My wife (who works in the medical field) tried to help me “get used to” needles and I didn’t make a single lick of progress. With my kind of issue, it’s common that the issue gets worse and not better if you get shots more often. Something about my subconscious forming a feedback loop with my reactions to create worse reactions over time. I didn’t stop breathing from shots when the symptoms started when I was 8 or 9, just got dizzy/lightheaded and passed out.

                • @[email protected]
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                  12 years ago

                  That sounds insanely distressing. I won’t recount my bad experiences. None of them were harmful, but some nurses aren’t as gentle as others.

    • @[email protected]
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      92 years ago

      Miniatyrize ultrasound part, make it communicare with those glucose sensors that are placed on shoulder, make it portable enough and Presto! Artificial pancreas.

    • @[email protected]
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      52 years ago

      I’m dumb…what does being diabetic have to do with inability to get needle vaccines? I’m seriously asking.

      • @[email protected]
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        2 years ago

        The pancreas is an organ which produces a hormone called insulin, which regulates the intake of sugar from the blood.

        In type 1 diabetics, the pancreas has been damaged by an autoimmune reaction, so they need to monitor their blood sugar and administer insulin to the blood using external equipment.

        This can be done manually with a needle and glucose tester for measuring blood sugar, and a syringe for administering insulin, or an insulin pump and continuous glucose monitor, which adhere to the skin and have continuous access to the blood through a cannula.

        Being able to administer insulin without a needle or cannula would eliminate a common point of failure in this system. The cannula of an insulin pump can easily become dislodged from the skin when disturbed and leak insulin onto the surface, resulting in high blood sugar and wasted insulin.

      • @[email protected]
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        132 years ago

        There’s type 1 and 2 diabetes. I believe type 2 requires you to regularly prick your fingers to test your blood sugar levels several times a day while type 1 requires mandatory insulin shots into your stomach a few times a day. Basically a diabetic fuckin hates needles for good reason and to be able to do that with ultrasound would be rad.

      • @[email protected]
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        2 years ago

        It could be that if vaccines can be attached to a “cup-like protein” and given through the skin, than maybe insulin could too. Just less needle sticks overall

  • Chaotic Entropy
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    Sitting for a minute and a half, not including prep and cleanup, or just getting stabbed a little. shrug

    Edit: To save the next half dozen people exclaiming “needles!” the trouble. I would refine my point to, “great to have the option but I imagine it as being more of a fallback than the beginning of a new era”.

    • @[email protected]
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      32 years ago

      It’s certainly less time effective if administering vaccines to large populations at once, but the increased antibody generation could absolutely make it worth it. Don’t know much about these things, but could mean the difference between two jabs and one 1.5 minute appointment.

    • @[email protected]
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      22 years ago

      Maybe one way of looking at it might be : this would be safe enough you could trust people to self-administer, and you could therefore take the professional with the needle out of the equation.

      90 seconds of one person’s time has got to be better than the quick jab by two people, no?

      • Ech
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        22 years ago

        I don’t think any amount of de-specializing would be enough to trust the ignorant and/or malicious masses could or would self-administer adequately.

        • @[email protected]
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          12 years ago

          You’re right. Can’t just post them to folks and expect 100% uptake. It might widen the possibilities of more people getting more vaccines, though. In my books, this can only be a good thing.

      • Chaotic Entropy
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        Depending on how specific the injection needs to be, there are a number of scenarios in which people can self-administer injections. So, ignoring people who physically can’t self-administer, it isn’t that dramatic a change.

        I can’t help but feel that the professional would be even more necessary to administer this correctly and not just waste a treatment/dose doing it wrong, whilst under the illusion that you did it right. Along with the specialised equipment needed for it in the first place. Needles and doses at least are pretty easily self-contained and if it is suitable for self application just “pointy end goes in fat bit of you”.

        Naturally it’s early days, so it’ll be fascinating to see how this develops.

        • @[email protected]
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          I agree! Auto injectors aren’t cheap compared to ye olde trusty ampule and syringe, and this might push the costs towards the higher end again. I can see a kids-and-the-latex-allergic edge case scenario.

          Can’t wait to see what develops 😄

    • @[email protected]
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      82 years ago

      I’ll take it over having a sore arm for a day or two.

      Getting a shot isn’t a big deal, but neither is sitting for five minutes.

    • mechoman444
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      32 years ago

      It’s not just the time we’ve saved here. Think of people on insulin that have to take shots multiple times a day.

      The medical implications of this are massive it is absolutely a game changer.

      If it ever comes into fruition.

      • Chaotic Entropy
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        12 years ago

        We’ll have to wait and see how this impacts anything that needs to be injected deeper than skin level, which is why the focus is on vaccines.

    • @[email protected]
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      162 years ago

      Needle phobias are extremely common, and the thing about phobias is that you’re fully aware that the fear isn’t coming from a rational place, which is part of what makes them so frustrating to deal with.

      • @[email protected]
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        12 years ago

        the thing about phobias is that you’re fully aware that the fear isn’t coming from a rational place

        Lol yeah when I get vaccinated the anxiety fully fades the moment the needle enters my arm.

    • @[email protected]
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      202 years ago

      For people like me who go down for a half hour and feel like a train wreck for 8 hours when they get stabbed a little, I’ll take a 1.5min one.

      If you told me I needed to run on a treadmill for an hour while the ultrasound worked, I’d STILL take it over getting stabbed a little.

      • Chaotic Entropy
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        112 years ago

        If humans weren’t meant to stabbed then we wouldn’t be so soft and penetrable.

        I do take your point though.

        • @[email protected]
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          32 years ago

          Lol, it’s true. But if we were meant to be stabbed we wouldn’t have a completely unique dangerous (occasionally it kills people) reaction to it that doesn’t resemble most phobias.

        • @[email protected]
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          2 years ago

          Happens for blood draws as well, even small quantities. Happens if someone pokes me with a lidocaine. It’s a vasovagal reaction where my body “overreacts to certain triggers”. My blood pressure and heartrate plummet (to scary low levels. I’ve freaked out nurses on a couple of occasions). It causes me to feint in a comically dramatic way because the bloodflow to my brain gets too low. To be even more fun, I sometimes exhibit false “seizure” symptoms when I’m down, tightening up all my muscles at once and stopping breathing. During my first COVID vaccine, my breathing stopped for almost a minute, which is why 2 doctors were overseeing me when I came to. My wife explaining the situation is the only reason I didn’t end up in an ambulance. You shoulda seen the nurse, she looked as pale as I did!

          In theory, this could kill me, and there are confirmed ultra-rare cases of people dying from vasovagal syncope. In practice, I’m far more likely to die of a car accident on the way home (with my wife driving me because I’m in no state to drive after that). So long as a competent medical professional is watching me, I’m basically completely safe. But absolutely miserable.

          Honestly, it makes me feel like I’m some kind of drama queen. But it’s entirely made up of unconscious responses in my body.

          And the weird thing is that it’s not thinking about needles. It’s my body’s reaction to the feeling of a needle entering it. That sad little “prick” feeling that is maybe a 1 out of 10 on the pain scale? I have no idea if it’s “trickable” because I have absolutely no problem digging out a splinter with a knife. I keep wanting to find out if getting a tattoo would trigger that reaction or not. I just want to get a tattoo anyway lol.

            • @[email protected]
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              22 years ago

              It fucking sucks, more because a lot of providers don’t (or didn’t. They’ve been getting better) take seriously. They’d treat you like a baby or a hypochondriac, right up until you scare them half to death by WHAT YOU SAID WOULD HAPPEN happening.

              The stopping-breathing thing is super-rare, so even people expecting that “complely calm-seeming patient” pass-out are shocked when that same unconscious patient starts holding their breath and shaking.

          • @[email protected]
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            12 years ago

            That sure sounds annoying. I hope being able to plan ahead for the occasional jab makes it not much of a real issue in your life.

            Does it happen for accidental/“natural” pokes? You mentioned the splinter thing, but if you had a thorn, cactus needle, or even a piece of glass stuck in your skin and pulled it out, would you do alright?

            • @[email protected]
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              I hope being able to plan ahead for the occasional jab makes it not much of a real issue in your life.

              Basically that. I schedule a day off if I need a jab for any reason, and work from home anyway when I’m miserable the next several days.

              Does it happen for accidental/“natural” pokes? You mentioned the splinter thing, but if you had a thorn, cactus needle, or even a piece of glass stuck in your skin and pulled it out, would you do alright?

              All of those are fine. And unlike a lot of people with my issue, blood doesn’t bother me in the least. Once in a great while I’ve gotten a mild version of that from an insect bite, but the feeling is just completely different.

              Oddly, I think if a needle hurt more and did some tearing, it wouldn’t bother me so much.

              But you’re asking some really thought-provoking questions. I have a lot of food-related texture issues and while this is COMPLETELY different, I’m suddenly wondering if it’s a little more similar than I thought. I do believe there’s a psychological component to it; I haven’t been able to test, but if I were surprised with a needle jab outside of a medical setting, I have no idea if it would happen to me or not.

              What I did discover is that my blood pressure doesn’t rise and my heartbeat doesn’t go up in “prep”. I don’t seem to have a stress-rise effect for it to be stress-plummet related. I’m not asking anyone to surprise me with a shot, but I really do wonder what would happen.

          • Ech
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            12 years ago

            Wow. That sucks. Wishing the best for you.

            • @[email protected]
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              22 years ago

              Honestly, I wouldn’t trade it for the medical conditions of some of my family and friends. It sucks, and makes me hate doctors, but it won’t kill me.

              I mean, I’d take this over diabetes and/or asthma shrug

    • Fogle
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      252 years ago

      Also stops a lot of medical waste

        • @[email protected]
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          152 years ago

          I don’t think there would be any need to dispose of any part of the ultrasound system; perhaps a disposable paper or plastic cover to speed up cleaning between patients. Meanwhile the needles are single use and must be disposed of properly since they are a bio-hazard. Can’t really see how a needle could possibly compete on the waste side of things.

    • Maeve
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      42 years ago

      Gosh, I’m sure they’ll latch on to that one.

  • @[email protected]
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    192 years ago

    If they can do this for insulin which sounds like it’s the same this is a game changer

    • @[email protected]
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      292 years ago

      I was gonna say oh now they are gonna say that’s what the 5g towers are REALLY for 🙄🙄🙄

      • @[email protected]
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        At this point if it was possible to orchestrate some massive conspiracy to vaccinate people en masse, we should just do that. They’ll shout about it either way, but this way they’ll at least be vaccinated

        • @[email protected]
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          52 years ago

          Torn between the dystopian abuse that will inevitably occur and thinking how funny it will be for a couple years.

        • @[email protected]
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          92 years ago

          This is basically the fluoride ‘debate’.

          (Yes, fluoridating the water supply is good.)

          • @[email protected]
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            12 years ago

            Also, if you are injesting enough flouride to cause health issues when you brush your teeth, you are brushing horrifically wrong.

          • kase
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            22 years ago

            I specifically remember my bio mom ranting about how we all would have telekinetic powers if not for the fluoride in the water. She believed that was the ‘real’ reason the government did it.

    • mechoman444
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      12 years ago

      That was my first thought the flat earthers and mud flood people are going to have a field day with this!

    • @[email protected]
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      Oh oh!

      They will say that ultrasounds is how they update the chips that are already in-vaccinated, to include new ways the deep state can control the population.

      You got to keep the narrative evolving.

      • @[email protected]
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        But the microchips are already equipped with 5G (and it even amplifies it, this is why our cell phone coverage is so good). Surely they can just push an OTA update, right?

      • @[email protected]
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        32 years ago

        Maybe you can help this make sense for me, as no one else has. We all know the government has proven to be corrupt, regardless of which party is in charge. We also know that Big Pharma is corrupt as hell too. Their goal is to keep us sick because healthy people don’t buy medicine. Now all of a sudden when they both say “Here take this shot otherwise you’ll kill grandma” we’re supposed to believe they have our best interest in mind? Like, why now? Why am I supposed to trust that what they say is safe and effective is actually that? I mean, drugs that have been used and studied for decades have been pulled of the shelf because it turns out it does more harm than good. It’s also been proven that the covid vaccine isn’t nearly as effective that they were touting.

        • Lemminary
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          You’re talking in such broad strokes that it’d take an entire essay to dissect what you’re saying.

          In short, there are areas of government and industry where corruption is a problem and others where it’s not, and yet regulation is still the norm. You frame it like it’s not that way at all and structure your argument around that. The reality is more complex with many other actors:

          we’re supposed to believe they have our best interest in mind?

          Yes. Neither big pharma nor the government are calling the shots all on their own. It’s not just business at play but public health along with the entire field of medicine and the research body. You’re completely ignoring the history of medicine and how it has shaped our global health sector.

          Epidemiologists around the world have been warning us about pandemics for decades, especially about coronaviruses since SARS hit Asia. These viruses are ancient and their potential is well studied. Only their mechanisms of infection are new.

          Like, why now?

          Because evolution happened right in front of our eyes and we happened to have a technology ready for it. mRNA vaccines have been 30 years in the making. Shit happened and we were the lucky winners. This is how history goes.

          Why am I supposed to trust that what they say is safe and effective is actually that?

          Because of science. Big effort is put into this by independent bodies by microbiologist, pharmacists, geneticists/molecular biologists, chemists, immunologists, etc. advancing their individual careers. Countless hours of labor has gone into making the technology possible and also painstakingly understanding the microbiology that makes it all possible. I think this arguably and easily goes back to the 70s. It’s not new and it’s not just one group behind this, even if only three people got the Nobel Prize for it within the last year.

          drugs that have been used and studied for decades have been pulled of the shelf because it turns out it does more harm than good

          Yes, and also many hundreds of others have endured and will continue to be safe within reason. The list of essential medications is incredibly long.

          As the saying goes, “if it can’t harm you, it can’t cure you,” because it means it doesn’t interact with your body in any way.

          The reasons for pulling drugs out of stores are incredibly varied and you can’t just dump them all into one bucket.

          One of those reasons is human error, another is uncertainty and yet another is lack of knowledge, among so many others. Not everything is a conspiracy.

          Instead, be grateful that our pharmacovigillance is working and that safer drugs are being made with new tech, like the mRNA vaccines.

          the covid vaccine isn’t nearly as effective

          Because of evolution. It’s an evolutionary arms race against a virus with a short mutation cycle that branches off into variants quicker than we can adjust our drugs. If the virus didn’t change, it’d have been exterminated the first year of the vaccines.

          Please let me know if I need to clarify, correct or expand on anything above. I’m happy to provide credible sources where needed.

        • @[email protected]
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          152 years ago

          I will try…

          Vaccines are studied by researchers from different affiliations, and published in peer-reviewed journals. Such studies require multiple stages, and when a vaccine is considered ready for the public, its side effects are already known.

          Big pharma is corrupt, but their main goal is money, and they get A LOT of money from selling vaccines. In the unlikely event of one company frauding a vaccine, this would be such a scandal that would affect its commercial relations in the entire world, thus, generating less profit in the long run and making investors move to other companies.

          The government is corrupt, but they want the population to be healthy enough to work, pay taxes and contribute to gdp. Giving room for simple diseases to kill people goes totally against the government’s goals.

          Remember, neither governments or companies want people to die, and curing lethal or disabling diseases goes in their own interests. Besides, we already have lots of chronic diseases and conditions around to continuously sell medicine.

          There’s no reason for any involved party to create fake vaccines and give it to people. If you’re really unsure, I recommend contacting universities and asking about assessment programs ( I don’t know how that would be called in english), because some places test samples from vaccines that will be used, in order to check if everything is ok. They probably publish the results too, and they’re not only experts in the field, but are independent parties.

          I hope this was of some help.

    • @[email protected]
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      52 years ago

      They will make up stories that ultra sounds scans is a nefarious way of vaccinating you without consent and consequently refusing to go to important checkups.

      They’re incredibly predictable. Just pretend to barely understand the subject matter, then invent the most alarmist way of misunderstanding it.